| IL-12在约氏疟原虫感染中作用的初步实验研究 |
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| 引用本文： | 姜素华,唐慧,邢建新. IL-12在约氏疟原虫感染中作用的初步实验研究[J]. 农垦医学, 2008, 30(5) |
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| 作者姓名： | 姜素华 唐慧 邢建新 |
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| 作者单位： | 石河子大学医学院,病原生物学与免疫学教研室,新疆石河子,832002;石河子大学医学院,形态学实验中心,新疆石河子,832002 |
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| 摘 要： | 目的:探讨IL-12在约氏疟原虫感染中的作用.方法:尾静脉注射法感染IL-12基因敲除小鼠和B6小鼠约氏疟原虫(17XNL),于感染后的第0、2或4、6天取小鼠尾静脉血,检测血清中的细胞因子;从感染后的第2天起,隔日检测小鼠虫体血症水平.结果:与B6小鼠相比,IL-12基因敲除小鼠在感染后虫体血症水平增长迅速且水平高;清除感染需时较长,但仍能完全清除虫体而存活.在感染后的第0、2、6天血清中无IL-12、IFN-γ,而B6小鼠IL-12、IFN-γ(D4)水平均较高.两者在TNF-α水平上无差别.结论:尽管IL-12对小鼠感染约氏疟原虫后的存活很重要,但无IL-12的小鼠感染约氏疟原虫后仍能存活.
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| 关 键 词： | 约氏疟原虫 虫体血症 细胞因子 |
Primary Research on Influence of IL-12 on Plasmodium yoelii Infection |
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| Jiang Suhua,Tang Hui,Xing Jianxing. Primary Research on Influence of IL-12 on Plasmodium yoelii Infection[J]. Agricultural Reclamation Medicine, 2008, 30(5) |
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| Authors: | Jiang Suhua Tang Hui Xing Jianxing |
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| Affiliation: | Jiang Suhua,Tang Hui,Xing Jianxing(Shihezi University School of wedicine,Xinjiang Shihezi,832002) |
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| Abstract: | Objective:To investigate the influence of IL-12 on Plasmodium yoelii infection.Methods:IL-12 kockout(KO) mice and B6 mice were infected intravenously with Plasmodium yoelii 17XNL parasitized red blood cells,their parasitemia were measured every two days from the second day after infection respectively.Cytokines in the serum of these mice were measured on the day 0,2 or 4 and 6 after infection.Results:The parasitemia of IL-12 kockout mice went up faster and higher,it took more time to clean the parasite,but ... |
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| Keywords: | Plasmodium yoelii parasitemia cytokine |
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