BINSWANGER病颈动脉IMT与IGF-1相关性研究

目的：探讨Binswanger病颈动脉内膜-中层厚度（inti ma-media thickness,I MT）和血清胰岛素样生长因子-1（insulin 1ike growth factor-1,IGF-1）的相关性。方法：54例经临床确诊为Binswanger病（Binswanger’s disease BD）患者（经神经心理学检测分为3组：轻度痴呆22例、中度痴呆17例、重度痴呆15例）和30例门诊健康体检志愿者,用二维超声检测颈动脉内中膜厚度,同时测定静脉血胰岛素样生长因子-1（IGF-1）水平,并进行统计分析。结果：BD组血清IGF-I水平均明显低于健康对照组（P〈0.05）,轻度痴呆组和中度痴呆组差异有统计学意义（P〈0.05）,中度痴呆组和重度痴呆组比较有显著性差异（P〈0.05）。血清IGF-I水平和颈动脉内膜-中层厚度呈中度负相关（r=-0.453）,BD患者的颈动脉内膜-中层厚度均明显高于对照组（P〈0.05）,轻度痴呆组和中、重度痴呆组之间差异有统计学意义（P〈0.05）,中、重度痴呆组之间差异有统计学意义（P〈0.05）。结论：血清IGF-1水平和颈动脉超声相结合,有助于BD痴呆程度的判断,为临床早期治疗BD提供可靠的依据。

Relative Research on IGF - 1 and IMT of Carotid Artery of Binswanger Disease

Objective:To explore the relation between the level of serum insulin 1ike growth factor-1(IGF-1)in patients with Binswanger's disease and their intima-media thickness(IMT)of carotid artery.Methods: Fifty-four patients suffering from Binswanger's disease were divided into 3 groups by neuropsychological test(1group mild dementia,2 group moderate dementia,3 group severe dementia) and thirty healthy volunteers constituted normal group underwent carotid artery ultrasonography.the serum IGF-1 level were measured ...