银杏叶提取物对轻度认知功能损害的影响

目的：观察银杏叶提取物对轻度认知功能损害（MCI）的影响。方法：MCI患者245例，随机分为治疗组（n=123）与对照组（n=122），两组均予基础治疗，治疗组加用银杏叶提取物40mg，1天3次，口服。两组治疗前、治疗6个月及1年行简易精神状态检查（MMSE）与画钟试验（CDT）。监测治疗前后两组红细胞乙酰胆碱（RBC-Ach）及红细胞乙酰胆碱酯酶（RBC—AchE）活性。结果：治疗6个月及1年，治疗组MMSE、CDT积分均显著提高，且均高于同期对照组（P〈0．01）；与治疗前比较，治疗1年治疗组RBC—Ach含量显著升高（P〈0．01），且高于对照组（P〈0．01）；治疗组RBC—AchE活性水平显著下降（P〈0．01），且低于对照组（P〈0．01）。结论：银杏叶提取物能显著改善MCI患者认知功能，降低AD转化率，可能与其改善中枢胆碱能系统功能有关。

Effect of Ginkgo Biloba Extract on Mild Cognitive Impairment

Objective：To observe the therapeutic effect of Ginkgo biloba extract on mild cognitive impairment（MCI）. Methods：A total of 245 MCI patients were randomly divided into treatment group （n=123） and control group （n= 122）. Both groups received basal therapy and the treatment group was given 40 mg Ginkgo biloba extract orally,3 times per day in addition. Mini-mental state examination（MMSE） and clock drawing task（CDT） were carried out to examine the patient＇s mental state before and half a year and 1 year after treatment. Serum RBC-Ach and RBC- AchE were determined in both groups before and after treatment. Results： In half a year and 1 year treatment,the patient in treatment group had higher scores in MMSE and CDT compared with control group at each time point （all P〈0.01）. Compared with that before treatment and that in control group,RBC-Ach was higher and RBC-AchE was lower in patients in treatment group after 1-year treatment （all P〈0.01 ）. Conclusion： Ginkgo biloba extract can improve cognitive activity and reduce the conversion rate of MCI to Alzheimer＇s disease in patients with MCI,which may be realized by regulating central cholinergic system.