| Wnt/β-catenin信号通路与胰腺癌相关性的研究进展 |
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| 引用本文： | 崔雨萌[综述],李骢[审校].Wnt/β-catenin信号通路与胰腺癌相关性的研究进展[J].肿瘤研究与临床,2013(12):856-858. |
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| 作者姓名： | 崔雨萌[综述] 李骢[审校] |
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| 作者单位： | [1]大连医科大学2009级七年制硕士研究生班,116044 [2]大连医科大学病理生理教研室,116044 |
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| 摘 要： | Wnt信号通路是调节细胞增殖、分化及移型的经典通路之一.Wnt蛋白可与多种不同Wnt蛋白受体结合,激活细胞内不同的信号通路,研究证实Wnt/β-catenin信号通路与胰腺癌的发生发展密切相关.对Wnt/β-catenin信号通路在细胞周期、细胞凋亡、肿瘤干细胞及血管生成方面对胰腺癌发生发展的影响进行综述.
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| 关 键 词： | 胰腺肿瘤 Wnt β-catenin信号通路 细胞周期 细胞凋亡 肿瘤干细胞 血管生成 |
Relationship between Wnt/β-catenin signaling pathway and pancreatic cancer |
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| Institution: | CUI Yu-meng,LI Cong(Seven-Year System Program of Clinical Medicine 2009 Grade, Dalian Medical University, Dalian 116044,China) |
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| Abstract: | Wnt signaling pathway is one of canonical pathways that can regulate diverse processes such as cell proliferation,differentiation,migration.Interaction between Wnt ligands and Wnt receptors results in an activation ofdifferent intracellular signaling pathways,and Wnt/β-catenin signaling pathway has been proved to have a close relationship with pancreatic cancer.This review presents a brief overview of Wnt/β-catenin signaling pathway in the mechanism of the tumorigenesis of the pancreatic cancer at deregulation of cell cycle,apoptosis,cancer stem cells and angiogenesis. |
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| Keywords: | Pancreatic neoplasms Wnt/β-catenin signaling pathway Cell cycle Apoptosis Tumor stem cells Angiogenesis |
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