中西药联合治疗多囊卵巢综合征所致不孕临床观察

目的：观察中西药联合治疗多囊卵巢综合征所致不孕的临床疗效。方法：多囊卵巢综合征所致不孕患者40例，随机分为西药组和中西药组各20例；两组均先予达因-35治疗3个月后西药组予氯米芬诱发排卵治疗，中西药组予氯米芬联合中药诱发排卵治疗。结果：40例患者予达因-35治疗3个月后性激素水平较治疗前均有明显改善；诱发排卵治疗后，中西药组妊娠率60％，明显高于西药组的25％（P〈0．05），卵泡发育、子宫内膜厚度、基础体温改善优于西药组，两组比较，差异有统计学意义（P〈0．05）；两组治疗后未妊娠者月经周期均有不同程度的缩短。结论：达因-35能有效调节性激素水平，为诱发排卵治疗创造有利条件；中药可能通过调节下丘脑-垂体-卵巢性腺轴功能和改善子宫内膜容受性，克服氯米芬“抗雌激素样作用”，促进卵泡发育和黄体功能，从而提高妊娠率，具有较好的临床疗效。

Infertility Treatment in Polycystic Ovary Syndrome with Traditional Chinese Medicine Combined with Western Medicine

Objective：To observe the clinical effect of using Chinese medicine combined with western medicine in the treatment of infertility in patients with polycystic ovary syndrome. Methods： Forty patients that met the diagnos- tic criteria of this research were randomly divided into western medicine group（A） and Chinese medicine combined with western medicine group （B）. Both groups were given diane-35 for 3 months,and then group A was adminis- tered with clomiphene citrate （CC） alone,while group B was given CC combined with traditional Chinese medicine to induce ovulation. Results：All patients showed significant improvement in sex hormone levels after 3 months of treatment with Diane-35 compared with pre-treatment. Ovulation induction treatment showed that the pregnancy rate of group B（60%） was significantly higher than that of group A（25%）（P〈O.05）. Group B had better improvement in follicular development,endometrial thickness,and basal body temperature （P〈0.05）compared with group A. After treatment,non-pregnant patients＇ menstrual cycle had different degrees of shortening. Conclusion：Diane-35 can ef- fectively regulate the sex hormone levels to create favorable conditions for ovulation induction treatment. Chinese medicine may regulate the function of the hypothalamus-pituitary-ovarian axis,improve endometrial receptivity to overcome the Janti-estrogen-like＇ effects of CC,and promote follicular development and luteal function,thus improve the pregnancy rate and achieve better clinical efficacy in infertility treatment.