间充质干细胞-抗肿瘤基因复合物治疗肿瘤的研究进展

间充质干细胞（MSC）是一种具有高度自我更新能力及多向分化潜能的细胞.MSC对多种肿瘤组织的归巢及定向迁移能力为其成为潜在的抗肿瘤基因载体奠定了基础,并且MSC自身参与重塑肿瘤微环境,影响其侵袭、增殖和转移等生物学行为.许多研究已经证实肿瘤坏死因子相关凋亡诱导配体（TRAIL）与人类第10号染色体缺失的磷酸酶及张力蛋白同源基因（PTEN）等抗肿瘤基因与MSC结合构成复合物可针对肿瘤细胞双重靶向杀伤,但对正常组织无损伤.然而,目前许多问题和确切的机制仍尚待解答.文章就MSC归巢机制、MSC对肿瘤生物学行为的影响和MSC-抗肿瘤基因复合物用于肿瘤治疗的现状及前景等进行综述.

Research progress of mesenchymal stem cell-antitumor gene complexes in cancer treatment

Mesenchymal stem cell （MSC） possesses highly self-renewal properties and potential ability of multiple differentiations.The homing and directional migration of MSC to tumors makes MSC uniquely destined as a potential anti-tumor gene carrier.MSC itself is discovered involved in remodeling the tumor microenvironment and regulating the biological behaviors of tumor cells such as invasion,proliferation and migration.Anti-tumor genes,such as tumor necrosis factor-related apoptosisinducing ligand （TRAIL） and phosphatase and tensin homologue deleted on chromosome 10 （PTEN） combine MSC to constitute a complex dually targeting tumor cells for destruction,but no damage to normal tissue.However,many questions remain to be answered and the precise mechanisms remain unclear.In this article,the current situation and prospects of the homing mechanism of MSC,the effects of MSC to tumor biological behavior and MSC-antitumor gene complex for tumor therapy are reviewed.