胶质瘤干细胞及其相关信号通路的研究进展 |
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引用本文: | 黄俊强[综述],杨妤[综述],杨立坚[审校].胶质瘤干细胞及其相关信号通路的研究进展[J].肿瘤研究与临床,2013(12):853-855. |
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作者姓名: | 黄俊强[综述] 杨妤[综述] 杨立坚[审校] |
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作者单位: | [1]湖南省长沙市第一医院神经外科,410000 [2]解放军第一六三医院肿瘤科,410000 |
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摘 要: | 胶质瘤是颅内常见的原发肿瘤,高级别的胶质瘤治疗效果不佳,对放化疗抵抗.目前认为在胶质瘤组织中存在着胶质瘤干细胞,此种细胞具有自我更新和分化的能力,是高级别胶质瘤放化疗失败的主要原因,针对胶质瘤干细胞的靶向治疗可能相对于传统放化疗能更好地改善高级别胶质瘤的预后.一些新的治疗手段通过作用于胶质瘤干细胞信号通路可靶向治疗胶质瘤.
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关 键 词: | 神经胶质瘤 干细胞 信号传导 |
Research progress of glioma stem cells and the related signal transduction pathways |
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Institution: | HUANG Jun-qiang,YANG Yu, YANG Li-jian(Department of Neurosurgery, the First Hospital of Changsha, Changsha 410000,China) |
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Abstract: | Gliomas harbor a small population of cells termed glioma stem-like cells (GSC),which have the ability to undergo self-renewal and initiate tumorigenesis.GSCs are resistant to a wide variety of chemotherapeutic agents and possess a remarkable ability to recover from cytotoxic therapy.Furthermore,GSCs play a crucial role in RT failure,as tumors surviving RT are enriched in GSCs.Therefore,an alternative strategy involving selective targeting of this functionally distinct chemo-and radiation resistant small group of GSCs rather than the bulk of the tumor may be more successful in treating this deadly disease.GSC exhibit various alterations to signaling pathway activity,which are associated with self-renewal and neoplastic proliferation.These altered pathways may represent possible targets for GSC. |
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Keywords: | Glioma Stem cells Signal transduction |
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