Tumour reducing and anticarcinogenic activity of Acanthus ilicifolius in mice. |
| |
Authors: | B H Babu B S Shylesh J Padikkala |
| |
Institution: | Department of Biochemistry, Amala Cancer Research Centre, Amala Nagar, 680 553, Thrissur, India. |
| |
Abstract: | Alcoholic extract of Acanthus ilicifolius (250,500 mg/kg b wt) was found to be effective against tumour progression and carcinogen induced skin papilloma formation in mice. The extract was found to be cytotoxic towards lung fibroblast (L-929) cells in 72 h MTT assay and the concentration required for 50% cell death was 18 microg/ml. Oral administration of the extract (500 mg/kg b wt) reduced the tumour volume and administration of the same concentration increased the life span by 75% in ascites tumour (EAC cells) harbouring animals. The extract also significantly delayed the onset of dimethylbenzanthrazene DMBA/Croton oil induced skin papilloma in mice in a dose dependent manner. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|