雷公藤中倍半萜生物碱的分离与结构鉴定

目的 对卫矛科雷公藤属植物雷公藤地上部分(Tripterygium wilfordii Hook. f . )进行化学成分研究。方法 利用多种色谱方法进行成分分离，根据物理化学性质和波谱学分析对化合物进行结构鉴定。结果 从雷公藤地上部分的乙醇提取物中分离得到7 个倍半萜生物碱类化合物，分别鉴定为 wilforgine (1)、euonine (2)、euonymine (3)、peritassine A(4)、wilfordinine E(5)、aquifoliunine E-III(6)、2-O-deacetyl-euonine(7)。结论 化合物6、7 为首次从雷公藤属植物中分离得到。

The isolation and structural identification of sesquiterpene alkaloids from Tripterygium wilfordii

Aim To isolate and identify the constituents of ethanol extract from Tripterygium wilfordii . Methods The compounds were isolated by the silica gel columns, preparative TLC and Sephadex LH-20, and their structures were identified by the physico- chemical properties and the spectral analysis. Results Seven compounds were isoated from the ethanol extract of Tripterygium wilfordii and identified as wilforgine (1), euonine (2), euonymine (3), peritassine A(4), wilfordinine E(5), aquifoliunine E-III(6), 2-O-deacetyl- euonine(7). Conclusions Compounds 6,7 were obtained from the Tripterygium genus for the first time.