| 尿脱氧吡啶啉及骨源性碱性磷酸酶在骨质疏松症中的临床意义 |
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| 引用本文： | 霍维玲,陈新军,李香业,王建强,王继华.尿脱氧吡啶啉及骨源性碱性磷酸酶在骨质疏松症中的临床意义[J].中国骨质疏松杂志,2005,11(2):181-183. |
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| 作者姓名： | 霍维玲 陈新军 李香业 王建强 王继华 |
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| 作者单位： | 1. 221006,徐州医学院第二附属医院骨科
2. 徐州医学院第二附属医院检验科 |
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| 摘 要： | 目的探讨骨源性碱性磷酸酶(BAP)及尿脱氧吡啶啉(DPD)排泄率对骨质疏松症患者的诊断价值及两者的相关性。方法对73例骨质疏松症患者在其治疗前后进行血钙(Ca)、血磷(P)、血碱性磷酸酶(ALP)、血BAP、尿DPD、尿Cr及跟骨密度(BMD)测定,并同时测定50例正常健康人作对照。结果骨质疏松症患者BAP比正常对照组(213±8．13U／L 比142±6．69U／L)、DPD排泄率较正常对照组(6．11±2．14nmol／mmolCr比3．24± 1．62nmol／mmolCr)均明显增高(P<0．01),且治疗前后差异有显著性(P<0．01)。两者之间成正相关(r=0．52)。结论 BAP、DPD／Cr是监测骨质疏松症患者的敏感指标。
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| 关 键 词： | 骨源性碱性磷酸酶 骨质疏松症 临床意义 尿脱氧吡啶啉（DPD） 正常对照组 血碱性磷酸酶 治疗前后 正常健康人 诊断价值 同时测定 敏感指标 排泄率 BAP 患者 相关性 骨密度 显著性 正相关 Cr |
| 修稿时间： | 2004年8月1日 |
Clinic significance of urinary deoxypyridinoline and bone alkaline phosphatase in osteoporosis |
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| HUO Weiling,CHEN Xinjun,LI Xiangye,et al..Clinic significance of urinary deoxypyridinoline and bone alkaline phosphatase in osteoporosis[J].Chinese Journal of Osteoporosis,2005,11(2):181-183. |
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| Authors: | HUO Weiling CHEN Xinjun LI Xiangye |
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| Institution: | HUO Weiling,CHEN Xinjun,LI Xiangye,et al. The Second Affiliated Hospital of Xuzhou Medical College,Xuzhou 221006,China |
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| Abstract: | Objective To investigate diagnostic value and association of BAP and excretion rate of DPD in osteoporosis. Methods Seventy-three patients with osteoporosis were tested for Ca2 , P, ALP, BAP in serum, DPD, Cr of urine and BMD of Nol to 4 lumbar vertebra and the results was compared with that of 50 healthy people. Results Both of the BAP and excretion rate of DPD were higher than the control groups (P<0. 01) , and there was a great difference after therapy (P<0. 01) . A positive correlation was found between BAP and DPD/Cr. Conclusions BAP and DPD/Cr are sensitive index in monitoring osteoporosis. |
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| Keywords: | Urinary deoxypyridinoline Bone alkaline phosphatase Osteoporosis |
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