Zollinger-Ellison syndrome

Opinion statement  The first goal of therapy is the control of gastric acid hypersecretion using PPIs or high-dose H2R antagonists.

–	The diagnosis of Multiple Endocrine Neoplasia (MEN I) should be established early in the disease.
–	Localization of gastrinoma tumor should be performed using a combination of endoscopic ultrasonography (EUS), somatostatin receptor scintigraphy (SRS), and computerized tomography (CT), or Magnetic Resonance Imaging (MRI).
–	Surgical resection in sporadic ZES should be performed to attempt cure of tumor.
–	Surgery, hormonal, chemotherapy, embolization therapy or therapeutic OctreoScan should be considered in patients with metastatic tumor.