| 病毒基因型对联合抗病毒治疗慢性乙型肝炎患者的HBV DNA、HBeAg变化的影响 |
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| 引用本文： | 汤佳良,许文芳,吴勇. 病毒基因型对联合抗病毒治疗慢性乙型肝炎患者的HBV DNA、HBeAg变化的影响[J]. 中国卫生检验杂志, 2011, 0(12): 2905-2906 |
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| 作者姓名： | 汤佳良 许文芳 吴勇 |
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| 作者单位： | 浙江省绍兴市斗门人民医院;浙江省绍兴市第六人民医院; |
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| 摘 要： | 目的:分析慢性乙型肝炎患者在拉米夫定和阿德福韦酯联合治疗过程中不同基因型对HBV DNA、HBeAg及ALT变化的影响。方法:对2009年9月-2011年3月在我院就诊的51例服用拉米夫定和阿德福韦酯慢性乙型肝炎患者进行基因分型、HBV DNA及肝功能指标的测定。结果:51例患者的HBV病毒基因型主要为B和C型,C型32例,占62.7%,B型19例,为37.3%,以C型基因型为主;B、C不同基因型组在治疗48周后,除12周时的HBV DNA、HBeAg有统计学意义,其余均无显著性差异。结论:拉米夫定和阿德福韦酯联合治疗的慢性乙型肝炎患者在治疗12周时,B和C基因型对患者的HBV DNA、HBeAg的变化有影响;但随着治疗时间的延长,基因型对HBV DNA、HBeAg及ALT的变化均无显著影响。
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| 关 键 词： | 慢性乙型肝炎 拉米夫定 阿德福韦酯 基因分型 HBV DNA HBeAg |
The influence of hepatitis B virus genotypes on HBV DNA and HBeAg in the combination therapy in patients with chronic hepatitis B |
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| TANG Jia-liang,Xu Wen-fang,WU Yong. The influence of hepatitis B virus genotypes on HBV DNA and HBeAg in the combination therapy in patients with chronic hepatitis B[J]. Chinses Journal of Health Laboratory Technology, 2011, 0(12): 2905-2906 |
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| Authors: | TANG Jia-liang Xu Wen-fang WU Yong |
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| Affiliation: | TANG Jia-liang1,Xu Wen-fang2,WU Yong2 |
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| Abstract: | Objective:To analyze changes of the HBV DNA,HBeAg and ALT in different genotypes during the lamivudine and adefovir dipivoxil combination therapy in the patients with chronic hepatitis B.Methods: 51 patients with chronic hepatitis B in our hospital from September 2009 to March 2011,had taken lamivudine and adefovir dipivoxil were genotyped and the HBV DNA and liver function index were measured.Results: HBV genotypes of the 51 patients were mainly B type and C type,with C type as the dominant genotype,in whi... |
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| Keywords: | Chronic hepatitis B Lamivudine Adefovir dipivoxil Genotyping HBV DNA HBeAg |
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