| 大剂量地塞米松对ITP患者调节性T细胞及叉头状转录因子FoxP3表达的影响 |
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| 引用本文： | 陈琪,梁军兵,李婉红,牛津,陈赛,陈建霖.大剂量地塞米松对ITP患者调节性T细胞及叉头状转录因子FoxP3表达的影响[J].中国卫生检验杂志,2011(12):2879-2881. |
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| 作者姓名： | 陈琪 梁军兵 李婉红 牛津 陈赛 陈建霖 |
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| 作者单位： | 浙江省台州市中心医院; |
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| 摘 要： | 目的:观察特发性血小板减少性紫癜(ITP)患者调节性T细胞(Treg)和叉头状转录因子FoxP3的表达情况及地塞米松治疗前后的变化。方法:用流式细胞术检测ITP患者外周血Treg、FoxP3的表达情况并与正常人群进行比较、并同时记录大剂量地塞米松治疗前后ITP患者Treg、FoxP3的表达情况,比较激素治疗对机体免疫的影响。结果:ITP患者外周血中CD4+T细胞的比例显著低于正常组(P<0.05),CD4+CD25+Treg及CD4+CD25+T在总CD4+T细胞中所占比例也低于正常对照组(P<0.05)。ITP患者未经激素治疗前外周血中FoxP3表达比例明显低于正常对照组(P<0.05),经大剂量地塞米松治疗后Foxp3表达比例升高(P<0.05),与正常人群比较差别仍有统计学意义(P<0.05)。结论:ITP患者的Foxp3表达下降,CD4+CD25+Treg细胞患者数量减少,Treg及Foxp3在ITP的发生发展中起到重要作用,大剂量地塞米松可显著提高CD4+CD25+Treg及FoxP3的表达。
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| 关 键 词： | 调节性T细胞 FoxP3 地塞米松 血小板减少性紫癜 |
Effect of high-dose dexamethasone on Treg and Foxp3 in patients with immune thrombocytopenic purpura |
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| CHEN Qi,LIANG Jun-bin,LI Wan-hong,NIU Jin,CHEN Sai,CHEN Jian-lin.Effect of high-dose dexamethasone on Treg and Foxp3 in patients with immune thrombocytopenic purpura[J].Chinses Journal of Health Laboratory Technology,2011(12):2879-2881. |
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| Authors: | CHEN Qi LIANG Jun-bin LI Wan-hong NIU Jin CHEN Sai CHEN Jian-lin |
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| Institution: | CHEN Qi,LIANG Jun-bin,LI Wan-hong,NIU Jin,CHEN Sai,CHEN Jian-lin(Taizhou Central Hospital,Taizhou 318000,China) |
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| Abstract: | Objective:To investigate the expressions of regulatory T cells(Treg) and Foxp3 before and after high-dose dexamethasone therapy in immune thrombocytopenic purpura(ITP).Methods: Flow cytometry was used to analyze the expression of Treg and Foxp3 on lymphocyte of peripheral blood in ITP patient.Then the expression was compared with health people.At the same time,the expression of Treg and Foxp3 in ITP patients before and after therapy with high-dose dexamethasone was recorded to find the influence of hormonot... |
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| Keywords: | Regulatory T-cell FoxP3 Dexamethasone Thrombocytopenic purpura |
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