病毒性心肌炎和室性早搏患儿血清自身抗体测定

目的：研究病毒性心肌炎（ＶＭ）和室性早搏（ＶＰＣ）患儿血清抗心肌线粒体抗体和抗心磷脂抗体的改变。方法：检测了３８例ＶＭ不合并ＶＰＣ（ＶＭ组）、３１例ＶＭ合并ＶＰＣ（ＶＭ＋ＶＰＣ组）和２６例单纯室性早搏（ＶＰＣ组），患儿，同时检测４０名健康儿童为正常对照组。抗体检测采用酶联免疫吸附法（ＥＬＩＳＡ）。结果：ＶＭ组、ＶＭ＋ＶＰＣ组和ＶＰＣ组血清抗心肌线粒体抗体的阳性率分别为６３．２％、６４．５％和４２．

Determination of serum autoantibodies in child patients with viral and ventricular premature complexes

Objective To Search for the changes of serum anti-myocardium mitochondrial antibody and anticardialipin antibody in child patients with viral (VM)and ventricular premature complexes(VPC).Methods 38 cases of VM without VPC(VM group),31 cases of VM with VPC(VM VPC group),26 cases of simple VPC(VPC group)and 40 cases of healthy children were detected.The antibodies were detected by enzyme linked immunosorbent assay(ELISA).Results The positive rates of serum anti-myocardium mitochondrial antibody in VM,VM VPC and VPC groups were 63 5%,64 5% and 42 3% respectively.The positive rates of anticardialipin antibody were 47 4%,51 6% and 34 6%respectively.All were significantly higher than those in control group.Conclusion There were autoimmunity reaction in VM and VPC patients.Anti-myocardium mitochondrial antibody and anticardialipin antibody had some roles in the pathogenesis of VM and VPC.There were myocardium disorders in some children with simple VPC,so positive treatments were necessary.