| 绞股蓝总苷对老化小鼠脑中MAO和Na/K-ATP酶活性的影响 |
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| 引用本文： | 龚国清,钱之玉,周曙. 绞股蓝总苷对老化小鼠脑中MAO和Na/K-ATP酶活性的影响[J]. 中草药, 2001, 32(5): 426-427 |
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| 作者姓名： | 龚国清 钱之玉 周曙 |
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| 作者单位： | 中国药科大学药理教研室, |
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| 摘 要： | 目的：研究绞股蓝总苷对老化小鼠脑中MAO和Na/K-ATP酶活性的影响。方法：采用连续眼球后注射D－半乳糖1个月，造成小鼠老模型，观察绞股蓝总苷对老化鼠脑中单胺氧化酶（MAO）和Na/K-ATP酶的活性影响。结果：老化小鼠可造成脑中MAO活性的升高和Na/K-ATP活力的降低，而绞股蓝总苷在造模型同时ig给药，每日剂量75和150mg/kg下，能逆转小鼠因老化而产生的上述二种酶活性的改变。结论：绞股蓝革能对抗老化小鼠因衰老引起的MAO和Na/K-ATP酶的活性改变，从生化酶学角度，进一步阐明绞股蓝总苷的抗衰老作用。
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| 关 键 词： | 绞股蓝总苷 老化小鼠 单胺氧化酶 Na／K－ATP酶 |
| 文章编号： | 0253-2670(2001)05-0426-02 |
| 收稿时间： | 2000-11-16 |
| 修稿时间： | 2000-11-16 |
Effects of gypenosides on monoamine oxidase and Na/K-ATPase activities in brain tissues of aging mice |
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| GONG Guoqing,QIAN Zhiyu and ZHOU Shu. Effects of gypenosides on monoamine oxidase and Na/K-ATPase activities in brain tissues of aging mice[J]. Chinese Traditional and Herbal Drugs, 2001, 32(5): 426-427 |
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| Authors: | GONG Guoqing QIAN Zhiyu ZHOU Shu |
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| Affiliation: | Department of Pharmacology, China Pharmaceutical University, Nanjing Jiangsu 210009, China;Department of Pharmacology, China Pharmaceutical University, Nanjing Jiangsu 210009, China;Department of Pharmacology, China Pharmaceutical University, Nanjing Jiangsu 210009, China |
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| Abstract: | Object To study the effects of gypenosides on MAO and Na/K ATPase activities in brain tissues of aging mice Methods Models of aging mice were prepared by continuous post orbitol injection of 120 mg/kg D galactose for a month, then the effects of gypenosides on MAO and Na/K ATPase activities in brain tissues were investigated Results It was observed that MAO activity was increased and Na/K ATPase activity was decreased in brain tissues of aging mice models significantly; and these effects were reversible respectively by gypenosides ig of 75 and 150 mg/kg Conclusion The result that gypenosides could invert the changes of MAO and Na/K ATPase activities in brain tissues of aging mice, may provide a further explaination of the anti aging mechanism of gypenosides in molecule enzymology |
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| Keywords: | gypenosides aging mice monoamine oxidase Na/K ATPase |
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