122株临床真菌及其耐药性分析

目的：了解医院深部真菌感染状况及其耐药性，为指导临床用药提供依据。方法：对2004年临床真菌感染标本进行回顾性分析。结果：122株深部真菌感染占医院感染的9．4％，其中以白色念珠菌（白色假丝酵母菌）为主。5-氟胞嘧啶、两性霉素-B、制霉菌素对真菌保持较高体外抗真菌活性，敏感率分别为91．8％、86．1％、70．8％；但咪康唑、酮康唑、益康唑耐药率较高，分别为80．8％、79．4％、72．6％，其中益康唑中介达19．2％。结论：我院真菌感染以白色念珠菌为主。5-氟胞嘧啶，两性霉素B，制霉菌素是目前我院治疗真菌感染的有效药物。唑类抗真菌药耐药率较高，采取有效干预措施刻不容缓。

Analysis of 122 clinical fungi strains and their drug resistance

Objective: To investigate the infection status of hospital deep fungus and its drug resistance,and provide important information for clinical diagnosis and therapy.Methods: Clinical data of 122 patients with fungus infection in 2004 were analyzed retrospectively.Results: Infection rate of deep fungus was 9.4%,and the incidence of candida albicans infection was 63.9%.The susceptibility rates of isolated fungus to 5-fluorocytosine(5-FC),amphotericin B(AMB) and nystatin(NYS) were 91.8%,86.1% and 70.8%,respectively,and the drug resistant rates to miconazole(MIZ),ketoconazole(KET) and econazole(ECO) were 80.8%,79.4% and 72.6%,respectively.The middle drug resistance rate to ECO was 19.2%.Conclusion: Candida albicans is still the essential strain in hospital fungus infection.5-FC,AMB and NYC are effective for treatment of fungus infection. Evident resistance can be found in some antifungal drugs,especially azoles.Some effective measures should be taken to control hospital fungus infection.