Modulation of human neutrophil functions in vitro by Treponema denticola major outer sheath protein |
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| Authors: | Puthengady Thomas Bina Sun Chun Xiang Bajenova Elena Ellen Richard P Glogauer Michael |
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| Affiliation: | CIHR Group in Matrix Dynamics and Dental Research Institute, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada M5S 3E2. |
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| Abstract: | In this study of human polymorphonuclear leukocytes (PMNs), pretreatment with Treponema denticola major outer sheath protein (Msp) inhibited formyl-methionyl-leucyl-phenylalanine (fMLP)-induced chemotaxis, phagocytosis of immunoglobulin G-coated microspheres, fMLP-stimulated calcium transients, and actin assembly. Msp neither altered oxidative responses to phorbol myristate or fMLP nor induced apoptosis. Msp selectively impairs chemotaxis and phagocytosis by impacting the PMN cytoskeleton. |
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