| 兔四氯化碳实验性肝硬化模型的建立 |
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| 引用本文： | 金博,程留芳,孙涛,张志成. 兔四氯化碳实验性肝硬化模型的建立[J]. 海军总医院学报, 2005, 18(3): 129-131 |
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| 作者姓名： | 金博 程留芳 孙涛 张志成 |
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| 作者单位： | 海军总医院消化内科,北京,100037;解放军总医院消化内科,北京,100853 |
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| 摘 要： | 目的应用四氯化碳造成兔肝硬化模型.方法雄性新西兰大白兔给予皮下注射四氯化碳,每周2次,12周后检测肝脏病理改变及肝组织羟脯氨酸含量.结果四氯化碳注射12周后,兔肝组织出现典型的假小叶,肝组织羟脯氨酸含量较正常组升高3.5倍.结论此方法成功地建立了一种兔肝硬化动物模型.
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| 关 键 词： | 兔 肝硬化 四氯化碳 |
| 文章编号： | 1009-3427（2005）03-0129-03 |
| 收稿时间： | 2005-06-23 |
| 修稿时间： | 2005-06-23 |
The Development of Carbon Tetrachloride-Induced Cirrhotic Model in Rabbit |
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| JIN Bo, CHENG Liu-fang, SUN Tao, et al. The Development of Carbon Tetrachloride-Induced Cirrhotic Model in Rabbit[J]. Journal of Naval General Hospital of PLA, 2005, 18(3): 129-131 |
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| Authors: | JIN Bo CHENG Liu-fang SUN Tao et al |
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| Affiliation: | Department of Digestive Diseases, Naval General Hospital, Beijing 100037, China |
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| Abstract: | Objective To develope a carbon tetrachloride-induced cirrhotic model in rabbit. Methods Male New Zealand white rabbit was subcutaneously injected with carbon tetrachloride twice weekly, and the liver pathology and hepatic hydroxyproline content were examined 12 weeks after the injection. Results 12 weeks after carbon tetrachloride administration, the rabbit liver developed typical pseudo-lobule, and the liver hydroxyproline content increased 3.5 times compared to normal control. Conclusion A successive method to induce rabbit liver cirrhosis was developed. |
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| Keywords: | Rabbit Liver cirrhosis Carbon tetrachloride |
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