文拉法辛与帕罗西汀治疗抑郁症对照研究

目的：评价文拉法辛与帕罗西汀治疗焦虑症的疗效和不良反应。方法：将符合中国精神障碍分类与诊断标准第3版诊断标准的52例门诊或住院抑郁症患者，随机平分为两组，分别给予文拉法辛和帕罗西汀治疗，疗程6周。用汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）、临床疗效总评量表的病情严重程度（CGI—S1）和副反应量表（TESS）评定疗效和不良反应。结果：文拉法辛与帕罗西汀对抑郁症疗效接近，但前者起效更快，不良反应少于后者。结论：文拉法新是一种安全、有效的新一代抗抑郁药，可以作为治疗抑郁症的第一线用药。

A study of venlafaxine and paroxetine in the treatment of depressione

Objective:To compare with efficacy and side effects between venlafaxine and paroxetine in the treatment of depression.Methods:52 inpatients and outpatients with a diagnosis of depression according to the CCMD-3 criteria were involved in this study;they were randomly divided into the venlafaxine group(n = 26) and the paroxetine group(n = 26) for 6 weeks.Effects and side effects were evaluated with HAMD,HAMA, CGI-SI and TESS before and after the treatment.Results: Findings indicated that efficacy of venlafaxine was the similar to those of paroxetine.However,venlafaxine took effect more quickly and its side effects were less than paroxetine.Conclusions:Venlafaxine is an effective and safe antidepressant.It is suggested that venlafaxine could be used as a first-line antidepressant in the treatment of depression for the elder.