| 阿片耐药的系统内调节机制 |
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| 引用本文： | 刘晓艳[综述],;孙莉[审校].阿片耐药的系统内调节机制[J].麻醉与监护论坛,2008(1):34-36. |
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| 作者姓名： | 刘晓艳[综述] ;孙莉[审校] |
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| 作者单位： | 中国医学科学院肿瘤医院麻醉科,北京100021 |
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| 摘 要： | 疼痛治疗目前仍主要依赖阿片药物，但阿片药物的耐药性给病人增加了极大的痛苦，严重影响了阿片药物的应用。目前的研究结果表明，阿片耐药的产生分为系统内和系统间两种机制。本文仅从阿片受体的系统内调节的角度，对阿片耐药的机制进行阐述，总结系统内调节机制的研究进展和热点问题。
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| 关 键 词： | 阿片药物 受体耐药 系统内调节 |
Intrasystemic Regulatory Mechanism of Opioid Tolerance |
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| Institution: | Xiao-yan Liu,Li Sun(Department of Anesthesiology,Cancer Institute＆Cancer Hospital,Chinese Academy of Medical Sciences,Peking Union Medical College,Peking 100021,China) |
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| Abstract: | Opioids are the most important drugs in pain therapy, but the tolerance induces anquish to patients greatly, and impacts the use of opioid drugs. The researches about opioid tolerance indicated that mechanisms of opioid tolerance could be divided into intrasystemic mechnism and intersystemic mechanism. This review expounded the intrasystemic mechanism of opioid tolerance, and summarized the advancements and warm spots of intrasystemic mechanism. |
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| Keywords: | Opoiods Tolerance Intrasystemic regulation |
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