| 乳腺癌组织中HER-2、PCNA、Bcl-2、Bax表达的临床意义 |
| |
| 引用本文： | 杨黎,朱霞,常建英,冉立.乳腺癌组织中HER-2、PCNA、Bcl-2、Bax表达的临床意义[J].中国药房,2011(30):2853-2855. |
| |
| 作者姓名： | 杨黎 朱霞 常建英 冉立 |
| |
| 作者单位： | 贵州省肿瘤医院乳腺妇瘤科; |
| |
| 摘 要： | 目的:研究原癌基因人表皮生长因子受体2(HER-2)、细胞增殖标志物增殖细胞核抗原(PCNA)和凋亡相关基因Bcl-2、Bax在乳腺癌组织中的表达及其与淋巴结转移、临床分期等因素的关系。方法:应用免疫组化Envision二步法检测50例乳腺癌根治术后标本中HER-2、PCNA、Bcl-2、Bax蛋白的表达。结果:乳腺癌组织中HER-2、PCNA、Bcl-2、Bax的表达率分别为44%、82%、48%、54%。HER-2表达率在淋巴结转移组增高(P<0.05);PCNA表达率在肿瘤直径大组明显增高(P<0.01);Bcl-2表达率与年龄、肿瘤大小、淋巴结转移及临床分期无关;Bax表达率在淋巴结转移组及临床分期晚组增高(P<0.05)。相关分析显示,HER-2、Bax表达与淋巴结转移呈正相关(P<0.05)。结论:联合检测HER-2、PCNA、Bcl-2、Bax可作为判断乳腺癌预后的可靠指标。
|
| 关 键 词： | 乳腺肿瘤 免疫组化 HER-2 PCNA Bcl-2 Bax |
Clinical Significance of HER-2,PCNA,Bcl-2 and Bax Expression in Breast Cancer Tissue |
| |
| YANG Li,ZHU Xia,CHANG Jian-ying,RAN Li.Clinical Significance of HER-2,PCNA,Bcl-2 and Bax Expression in Breast Cancer Tissue[J].China Pharmacy,2011(30):2853-2855. |
| |
| Authors: | YANG Li ZHU Xia CHANG Jian-ying RAN Li |
| |
| Institution: | YANG Li,ZHU Xia,CHANG Jian-ying,RAN Li(Dept.of Oncology,Guizhou Cancer Hospital,Guiyang 550000,China) |
| |
| Abstract: | OBJECTIVE:To study the expressions of HER-2,PCNA,Bcl-2 and Bax in breast cancer tissue and their relationships with lymph node metastasis,clinical stage and other prognostic factors.METHODS:The expressions of HER-2,PCNA,Bcl-2,and Bax in 50 specimens of breast cancer were detected by immunohistochemistry with Envision staining.RESULTS:The expression rates of HER-2,PCNA,Bcl-2 and Bax in breast cancer tissues were 44%,82%,48% and 54%,respectively.HER-2 positive expression rate was significantly high in lymph n... |
| |
| Keywords: | Breast neoplasm Immunohistochemistry HER-2 PCNA Bcl-2 Bax |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
