胃癌非细胞毒性化疗的研究

目的 研究非细胞毒性化疗药物对胃癌生长的抑制作用及机制。方法 观察胃泌素受体（GR）拮抗剂对胃癌细胞株MKN45移植瘤生长的抑制作用；在测定34例胃癌患达GR折基础上，对GR阳性的胃癌患加用丙从胺（PGL），评坐其初步临床效果。结果 PGL组移植面积、重量、胃癌细胞DNA指数、DNA含量及S期细胞比例均低于对照组，PGL＋SST组更低；晚期胃体癌、胃底贲门癌易于表达GR；对14例GR阳性的胃癌患随访6－21月，对照组8例患中有2例死亡，PGL组6例均存活，结论 PLG能调控胃癌细胞株MKN45移植瘤的生长，有望能改善胃癌患的预后。

THE STUDY OF NON-CYTOTOXIC CHEMOTHERAPY IN GASTRIC CANCER

objective To study the inhibition effect and its mechanism of a non - cytotoxic chemotherapy drug in the growth of gastric cancer. Methods The inhibition effect was observed in the growth of xenotransplanted gastric cancer cells MKN45 with a gastrin receptor(GR) antagonist. On the basis of the determination of expressed GR in 34 patients with gastric cancer, we evaluated the preliminary clinical effect of PGL to gastric cancer with the positive GR. Results It is less tumor area, weight and gastric cancer cells DNA Index, average DNA contents and S phase fraction in PGL group than in control group. It is the least in PGL + SST group. GR is easy to be expressed in advanced gastric cancer of the body, cardia and fundus. With the 16-21 months follow- up of 14 patients with positive GR gastric cancer, we find that 2 patients died in control group of 8 patients, and all patients are alive in PGL group. Conclusion PGL can regulate the growth of gastric cancer cells MKN45. It would be able to improve the prognosis of gastric cancer.