长期小剂量性激素替代疗法对绝经后妇女骨密度的影响

目的观察长期应用小剂量性激素替代疗法对绝经后妇女骨密度及骨关节痛发生的影响。方法选择北京协和医院141名绝经后医护人员,分为性激素替代治疗(HRT)组(n=63)和对照组(n=78)。HRT组接受小剂量HRT5~32年,对照组年龄与HRT组匹配,未接受HRT。比较两组治疗后腰椎、WARD三角、股骨颈、股骨粗隆和全髋总骨密度及骨关节痛的发生率。结果HRT组L2-4的骨密度比对照组高9·1%(P<0·05)。HRT组和对照组骨关节痛的发生率分别为71·4%和89·7%,两组相比差异具有显著性(P<0·05)。结论长期小剂量HRT可减少绝经后妇女骨量丢失,降低骨关节痛发生。

Effects of long-term and low-dose hormone replacement therapy on bone mineral density in postmenopausal women

Objective To observe the effects of long-term and low-dose hormone replacement therapy on bone mineral density (BMD), and the incidence of bone pain in postmenopausal women. Methods Totally 141 postmenopausal women were selected from the medical staff of the Peking Union Medical College Hospital. Of them, 63 women treated with low-dose sex hormone for over 5 (5-32) years were divided into hormone replacement therapy (HRT) group, and 78 never receiving HRT were divided into control group. The BMD was measured by dual energy X-ray absorptiometry (DEXA) at lumbar spine, Ward's triangle, femoral neck, trochanter, and total hip, and the incidence of bone pain was inquired. Results The BMD in the HRT group was 9.1% higher than that in the control group(P<0.05). The incidence of bone pain was significantly lower in the HRT group(71.4%) than that in the control group(89.7%). Conclusion Long-term and low-dose hormone replacement therapy can reduce bone loss and the incidence of bone pain.