嗜酸粒细胞增多综合征的治疗进展

嗜酸粒细胞增多综合征是病因不明,以骨髓、外周血和组织中嗜酸粒细胞增多为特点,并累及多器官的一组疾病,仅累及皮肤者称为嗜酸粒细胞增多性皮炎.传统药物如糖皮质激素、羟基脲、环孢素等均为非特异性作用药物,长期服用不良反应明显.近年发现,该病与嗜酸系融合基因或异常T淋巴细胞克隆有关,酪氨酸激酶抑制剂、干扰素α、白介素-5单克隆抗体等对该病有特异性疗效.

Therapeutic progress of hypereosinophilic syndrome

As a group of idiopathic diseases of unknown origin, hypereosinophilic syndrome is characterized by eosinophilia in bone marrow, peripheral blood and tissue usually with multiple-organ involvement. Eosinophilia dermatitis is specifically referred to eosinophilia in skin tissue. Conventional therapies like corticosteroids, hydroxyurea and cyclosporins are nonspecific and carry many side effects in the long run. Recently, it has been evidenced that hypereosinophilic syndrome is associated with fusion genes in eosinophils and abnormal T cell clones, and,tyrosine kinease inhibitors, interferon-α and anti-interleukin-5 monoclonal antibodies have specific efficacy for this disease.