慢性肺心病患者血浆α-颗粒膜蛋白及D-二聚体的变化

目的 研究慢性阻塞性肺部疾病（COPD）所致肺心病患者血小板活化、凝血激活的变化。方法 将研究对象分为肺心病急性加重期组（25例）、肺心病好转期组（25例）和正常对照组（20名），采用酶联免疫双抗体夹心法分别检测血小板颗粒膜蛋白（GMP－140）、D －二聚体浓度，对其结果进行统计学进行。结果 肺心病急性加重期和好转期患者的血浆GMP－140、D－二聚体浓度与正常对照组比较，差异有极显著性意义（P＜0．01）。急性加重期与好转期比较，差异有显著性意义（P＜0．01，P＜0．05）。结论 肺心病患者存在异常的血小板活化、内皮细胞受损及血液高凝状态，可能是肺心病发生发展的重要因素。

The change of plasma levels of a- granule membrane protein and D- dimer in patients with chronic

Objective To study the change of platelet activation and enhanced coagulability in patients with chronic pulmonary heart disease (COPD). Methods Plasma levels of a-granule membrane protein (GMP-140) and fibrin D-dimer were determined by two-layer antibody sandwich enzyme-linked immunosorbent assay in 25 patients with chronic pulmonary heart disease during the acute aggravating phase and 25 patients after relief 20 healthy people served as the controls. Results The plasma levels of GMP-140 and D-dimer in both groups of were higher than in the control group ( p <0.001). Those were also significantly in the patients during acute aggravating phase than in those after relief ( p <0.01, p <0.05). Conclusion Abnormality of platelet activation, endothelial damage and enhanced coagulability are the important factors affecting pulmonary heart disease.