Comparison of the antinociception produced by two oral formulations of ibuprofen: ibuprofen effervescent vs ibuprofen tablets |
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Authors: | T Hummel O Cramer P Mohammadian G Geisslinger E Pauli G Kobal |
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Institution: | (1) Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen-Nürnberg, Krankenhausstr. 9, D-91054 Erlangen, Germany, DE;(2) Department of Neurology, University of Erlangen-Nürnberg, Schwabachanlage 6, D-91054 Erlangen, Germany, DE;(3) Smell and Taste Center, Department of Otorhinolaryngology, University of Pennsylvania, 3400 Spruce Street, 5 Ravdin Pavilion, Philadelphia, PA 19104, USA thummel@mail.med.upenn.edu, US |
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Abstract: | Objective: The aim of this study was to compare the dose-related effects of both ibuprofen tablets and ibuprofen effervescent placebo,
400 and 800 mg ibuprofen (Aktren)] on phasic pain. Patients: Twenty volunteers participated in this randomized, double-dummy, fivefold crossover study. Methods: Measurements were obtained before and 15, 60 and 240 min after drug administration. Pain was produced by CO2 pulses applied to the left nostril. Subjects rated the intensity of the painful stimuli by means of a visual analogue scale.
In addition, chemosomatosensory event-related potentials were recorded. Results: In line with previous work, ibuprofen produced a dose-related decrease in pain-related potential amplitudes P1N1, indicating
its antinociceptive effects. Higher plasma concentrations of ibuprofen were reached 15–40 min after administration of the
effervescent while ibuprofen tablets had a tmax 60–90 min after administration. In addition, 60 min after intake of the effervescent a prolongation of the latencies of the
potentials was observed, possibly reflecting superior antinociceptive properties when compared to ibuprofen tablets. In addition,
the effervescent appeared to have more consistent effects on intensity estimates compared to ibuprofen tablets.
Received: 13 June 1996 / Accepted in revised form: 22 November 1996 |
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Keywords: | Key words Nociception Ibuprofen irritation anal-gesia human NSAID |
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