头孢唑啉钠中残留的7-ACA的定性定量分析

目的:根据国际要求,对头孢唑啉钠中残留的7-ACA进行定性定量测定,可以提高患者的用药安全度,减少过敏反应的发生。方法:本文采用质谱(MS)、红外吸收光谱(IR)与核磁共振谱(NMR)对7-ACA样品进行结构确认,然后作为对照品用高效液相色谱法(HPLC),根据相对保留时间测定其头孢唑啉钠中的残留。结果:表明所获得的7-ACA对照品纯度很高,适合对头孢唑啉钠作定性定量分析。结论:头孢唑啉钠中7-ACA的残留在安全限度之内。

Quantify and Identify the Assay of 7 - ACA in Cefazolin Sodium

Objective: The article detects the assay of 7-ACA in Cefazolin sodium in order to improve the administration security, and to decrease anaphylaxis, Methods: The article identifies 7 - ACA structure through MS, IR and NMR method, then using it as reference substance to quantify its assay in Cefazolin sodium with HPLC method according to relative retention time. Results: Our reference substance 7 - ACA is pure, and it is suitable to detect the residual content in Cefazolin sodium.Conclusion:The residual content complies with security specification.