| 血吸虫病化学治疗的研究——ⅩⅩⅩⅦ.β-(5-硝基-4-溴-2-呋喃)-及β-(4,5-二溴-2-呋喃)丙烯酰胺及其酯类的合成 |
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| 引用本文： | 徐懋丽,陆见明,雷兴翰.血吸虫病化学治疗的研究——ⅩⅩⅩⅦ.β-(5-硝基-4-溴-2-呋喃)-及β-(4,5-二溴-2-呋喃)丙烯酰胺及其酯类的合成[J].药学学报,1985,20(7):509-513. |
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| 作者姓名： | 徐懋丽 陆见明 雷兴翰 |
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| 作者单位： | 上海医药工业研究院 |
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| 摘 要： | 本文报道β-(4,5-二溴-2-呋喃)-及β-(5-硝基-4-溴-2-呋喃)丙烯酰胺及其酯类衍生物26个的合成。动物筛选结果表明;化合物Ⅲ6,Ⅲ8和Ⅲ13对感染日本血吸虫小白鼠有明显的治疗作用。化合物Ⅱ6有较明显的预防作用。
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| 关 键 词： | 抗血吸虫病药 β-(5-硝基-4-溴-2-呋喃)丙烯酰胺及酯类 β-(4 5-二溴-2-呋喃)丙烯酰胺及酯类 |
| 收稿时间： | 1984-11-05 |
Chemotherapeutic studies on schistosomiasis. XXXVII. Synthesis of derivatives of beta-(5-nitro-4-bromo-2-furyl)- and beta-(4,5-dibromo-2-furyl) acrylamides and esters |
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| KU Mao-Li,LU Jian-Ming and LEI Xing-Han.Chemotherapeutic studies on schistosomiasis. XXXVII. Synthesis of derivatives of beta-(5-nitro-4-bromo-2-furyl)- and beta-(4,5-dibromo-2-furyl) acrylamides and esters[J].Acta Pharmaceutica Sinica,1985,20(7):509-513. |
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| Authors: | KU Mao-Li LU Jian-Ming and LEI Xing-Han |
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| Abstract: | Twenty-six compounds of β-(4,5-dibromo-2-furyl)-and β-(5-nitro-4-bromo-2-furyl) acrylic amides and esters were synthesized. Among them, compounds Ⅲ6, Ⅲ8, Ⅲ13 and Ⅱ6 showed pronounced activity against Schistosoma japonicum in screening tests on mice. |
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| Keywords: | β-(5-Nitro-4-bromo-2-furyl) acrylic amides and esters β-(4 5-Dibromo-2-furyl) acrylic amides and esters Antischistosomal drug |
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