| 胰岛β细胞凋亡的分子机制 |
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| 引用本文： | 邓向群,陈璐璐. 胰岛β细胞凋亡的分子机制[J]. 国际内分泌代谢杂志, 2006, 26(3): 163-166 |
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| 作者姓名： | 邓向群 陈璐璐 |
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| 作者单位： | 430022,武汉,华中科技大学同济医学院附属协和医院内分泌科;430022,武汉,华中科技大学同济医学院附属协和医院内分泌科 |
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| 摘 要： | 胰岛β细胞凋亡在糖尿病的发病中扮演重要角色,1、2型糖尿病β细胞凋亡的分子机制有所不同。在1型糖尿病中,胰岛β细胞主要通过死亡受体介导的信号转导途径及颗粒酶B途径发生凋亡,而在2型糖尿病中,线粒体途径是胰岛β细胞凋亡的主要信号转导途径。多种细胞因子通过激活核转录因子调节相应基因表达,进而调控胰岛β细胞的凋亡。
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| 关 键 词： | β细胞 凋亡 分子机制 糖尿病 |
| 收稿时间： | 2005-04-10 |
| 修稿时间： | 2005-04-10 |
The molecular mechanisms of islet beta-cell apoptosis |
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| DENG Xiang-qun,CHEN Lu-lu. The molecular mechanisms of islet beta-cell apoptosis[J]. International JOurnal of Endocrinology and Metabolism, 2006, 26(3): 163-166 |
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| Authors: | DENG Xiang-qun CHEN Lu-lu |
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| Affiliation: | Department of Endocfinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China |
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| Abstract: | Islet beta-cell apoptosis plays an essential role in the onset of diabetes. The molecular mechanisms inducing apoptosis of beta-cells in type 1 and type 2 diabetes are different. In type 1 diabetes, signal transduction pathway mediated by death receptor and granzyme B pathway participate in the beta-cell apoptosis, however, the main transduction pathway leading to beta-cell apoptosis in type 2 diabetes is mitochondria pathway. Furthermore, many cytokines can regulate the related genes expression by activating nuclear factors, and then control apoptosis of beta-cell. |
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| Keywords: | Beta-cell Apoptosis Molecular mechanism Diabetes |
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