屈光参差性弱视儿童视网膜光学相干断层成像研究

目的：应用视网膜光学相干断层成像方法（OCT）研究屈光参差性弱视儿童视网膜神经纤维层（RNFL）和黄斑中心凹厚度，探讨弱视的发病机制。方法对屈光参差性单眼弱视儿童38例进行OCT检查，据弱视眼屈光状态分为远视散光弱视组18例，单纯远视弱视组20例，对侧健眼为正常对照组。分析比较三组视盘周围RNFL厚度和黄斑中心凹厚度的差异。结果远视散光弱视组、单纯远视弱视组和正常对照组视盘周围RNFL厚度分别为115.77±13.42μm、111.34±10.30μm 和103.05±11.10μm，黄斑中心凹厚度分别为198.86±28.30μm、191.98±27.81μm，181.18±29.06μm。两弱视组分别与正常对照组、两弱视组组间比较视盘周围RNFL厚度及黄斑中心凹厚度，差异均有统计学意义，P＜0.05。结论屈光参差性弱视其弱视眼视盘周围RNFL厚度及黄斑中心凹厚度较对侧正常眼增厚，且远视散光弱视眼厚于单纯远视弱视眼。

Retinal optical coherence tomography study on children with anisometropia monocular amblyopia

Objective To assess retinal nerve fiber layer and the fovea in children with anisometropic am-blyopia by optical coherence tomography（OCT）. Methods OCT was performed on 38 children with anisometropic am-blyopia. 18 children were astigmatic amblyopia and 20 children were hypermetropic amblyopia. The thickness of peri-papillary region retinal nerve fiber layer and the fovea were recorded and analyzed among amblyopia eyes and normal eyes. Results The thickness of mean peripapillary region RNFL and fovea were 115.77±13.42μm, 111.34＆±10.30μm, 103.05＆±11.10μm and 198.86＆#177;28.30μm, 191.98＆±27.81μm, 181.18＆±9.06μm respectively in the astigmatic amblyopia, hypermetropic amblyopia and normal eyes. The RNFL and fovea thickness in amblyopic eyes were thicker than those in normal eyes, and the RNFL and fovea thickness in astigmatic amblyopia were thicker than that in hypermetropic amblyopia, P〈0.05. Conclusions The thickness of RNFL and fovea in anisometropic amblyopia eyes were thicker than those in normal eyes. The thickness of RNFL and fovea in astigmatic amblyopia were thicker than those in hy-permetropic amblyopia.