| 异型南五昧子(Kadsura heteroclita)中的具有血小板活化因子(PAF)拮抗活性的联苯环辛烯类木脂素 |
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| 引用本文： | 韩桂秋,代平,薛荣,Byron R.Arison,David C.Lankin,San Bao Hwang. 异型南五昧子(Kadsura heteroclita)中的具有血小板活化因子(PAF)拮抗活性的联苯环辛烯类木脂素[J]. 中国药学, 1992, 0(1) |
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| 作者姓名： | 韩桂秋 代平 薛荣 Byron R.Arison David C.Lankin San Bao Hwang |
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| 作者单位： | 北京医科大学药学院，北京医科大学药学院，兰州军医学校化学系，Merck Sharp & Dohme Res.Lab.Rahway NJ07065，USA，G.D.Searle & Co，Skokie，IL60077，USA，Cytomed，Inc.，Cambridge，MA01701，USA，北京100083，北京100083，兰州730020 |
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| 基金项目： | This project was supported by National Natural Science Foundation of China. |
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| 摘 要： | 自异型南五味子(Kadsure heteroclita)首次分得7个已知的联苯环辛烯类木脂素,tigloylgomisin P(1),angeloylgomisin P(2),gomisin A(3),五味子素(4),angeloylgomisin H(5),gomisin B(6),R(+)-gomisin M(7)。tigloylgomisin P(1)的构型以二维核磁共振光谱技术确定。应用[~3H]血小板活化因子(PAF)结合人血小板膜的分析方法测定,证明化合物(1),(2)和(7)有 PAF 受体拮抗活性。
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| 关 键 词： | 异型南五味子 血小板活化因子受体拮抗剂 Tigloylgomisin P angeloylgomisin P R(+)—gomisin H 联苯环辛烯类木脂素 |
Dibenzocyclooctadiene Lignans with Platelet-Activating Factor (PAF) Antagonist Activity from Kadsura heteroclita |
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| Gui-Qiu Han Ping Dai Rong Xue Byron H.Arison David C.Lankin San Bao Hwang.School of Pharmaceutical Sciences,Beijing Medical University,Beijing ,,Dept.of Chemistry,Lanzhou Military Medical School,Lanzhou ,.Merck Sharp , Dohme Res.Lab,Rahway,NJ ,USA,.G.D.Searle , Co,Skokie,IL ,USA,.Cytomed Inc.,Cambridge,MA ,USA.. Dibenzocyclooctadiene Lignans with Platelet-Activating Factor (PAF) Antagonist Activity from Kadsura heteroclita[J]. Journal of Chinese Pharmaceutical Sciences, 1992, 0(1) |
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| Authors: | Gui-Qiu Han Ping Dai Rong Xue Byron H.Arison David C.Lankin San Bao Hwang.School of Pharmaceutical Sciences Beijing Medical University Beijing Dept.of Chemistry Lanzhou Military Medical School Lanzhou .Merck Sharp & Dohme Res.Lab Rahway NJ USA .G.D.Searle & Co Skokie IL USA .Cytomed Inc. Cambridge MA USA. |
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| Affiliation: | Gui-Qiu Han~1 Ping Dai~1 Rong Xue~2 Byron H.Arison~3 David C.Lankin~4 San Bao Hwang~51.School of Pharmaceutical Sciences,Beijing Medical University,Beijing 100083,2,Dept.of Chemistry,Lanzhou Military Medical School,Lanzhou 730020,3.Merck Sharp & Dohme Res.Lab,Rahway,NJ 07065,USA,4.G.D.Searle & Co,Skokie,IL 60077,USA,5.Cytomed Inc.,Cambridge,MA 01701,USA. |
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| Abstract: | Seven known dibenzocyclooctadiene lignans,tigloylgomisin P(1), angeloylgomisin P(2),gomisin A(3),Schizandrin(4),angeloylgomisin H(5),gomisin B(6) and R(+)-gomisin M_1(7)were isolated from Kadsura heteroclita.The conformation of tiglolylgomisin P(1)was established by 2D NMR techniques.Using[~3H]platelet activating factor(PAF)binding to human platelet membrane assay,(1),(2)and(7)showed PAF receptor antagonistic activities. |
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| Keywords: | Kadsura heteroclita PAF receptor antagonist Tigloylgomisin P Angeloylgomisin P R(+)-gomisin H Dibenzocyclooctadiene lignans |
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