Alginate/chitosan particulate systems for sodium diclofenac release. |
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| Authors: | M L González-Rodríguez M A Holgado C Sánchez-Lafuente A M Rabasco A Fini |
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| Institution: | Departamento de Farmacia y Tecnología Farmacacéutica, Facultad de Farmacia, C/Profesor Garcia Gonzalez s/n, Universidad de Sevilla, 41012, Sevilla, Spain. rabasco@fafar.us.es |
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| Abstract: | Alginate/chitosan particles were prepared by ionic gelation (Ca2+ and Al3+) for the sodium diclofenac release. The systems were characterized by electron microscopy and differential scanning calorimetry. The ability to release the active substance was examined as a function of some technological parameters and pH of dissolution medium. The release of sodium diclofenac is prevented at acidic pH, while is complete in a few minutes when pH is raised up to 6.4 and 7.2. The alginate/chitosan ratio and the nature of the gelifying cation allow a control of the release rate of the drug. The release mechanism was briefly discussed. |
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