| 黄芩素的抗肿瘤作用及机制的研究进展 |
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| 引用本文： | 毛捷,徐善水,盛莉莉,王宣之.黄芩素的抗肿瘤作用及机制的研究进展[J].中国临床药理学与治疗学,2009,14(10):1178-1182. |
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| 作者姓名： | 毛捷 徐善水 盛莉莉 王宣之 |
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| 作者单位： | 1. 皖南医学院弋矾山医院神经外科,芜湖,241001,安徽
2. 皖南医学院弋矾山医院肿瘤科,芜湖,241001,安徽 |
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| 基金项目： | 安徽省中医药研究课题 |
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| 摘 要： | 黄芩作为清热类中药广泛应用于临床,近年来国内外研究表明,黄芩中黄酮成分黄芩素,通过调节花生四烯酸系统的代谢,诱导肿瘤细胞周期停滞,诱导肿瘤细胞凋亡,抑制肿瘤新生血管生成,抗肿瘤侵袭和转移,增强肿瘤细胞对化疗药物的敏感性等机制发挥其抗肿瘤作用。本文对黄芩素抗肿瘤作用的研究现状及机制作一综述,为临床的进一步应用提供理论基础。
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| 关 键 词： | 黄芩素 抗肿瘤 机制 |
Advances in the studies on the anti-tumor effect and mechanism of baicalein |
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| MAO Jie,XU Shan-shui,SHEN Li-Li,WANG Xuan-zhi.Advances in the studies on the anti-tumor effect and mechanism of baicalein[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2009,14(10):1178-1182. |
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| Authors: | MAO Jie XU Shan-shui SHEN Li-Li WANG Xuan-zhi |
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| Institution: | 1Department of Neurosurgery; 2Department of Tumor, Yijishan Hospital, Wannan Medical College, Wuhu 241002, Anhui, China) |
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| Abstract: | Baicalein is applidied in clinic as Qing Re traditional Chinese herb.The recent research indicate that baicalein in scutellaria has anti-tumor effect by regulating arachidonic acid(AA)metabolites,inducing cancer cell cycle arrest and apoptosis,restraining tumor new angiogenesis,inhibiting cancer cell invasion and aversion,and enhancing cancer cell sensitiveness to chemotherapeutics.This article reviews the development of its anti-tumor effect and mechanism and provides theoretical evidence for clinical application. |
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| Keywords: | Baiealein anti-tumor mechanism |
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