解郁丸抗焦虑及催眠作用的实验研究

目的：研究解郁丸的抗焦虑及催眠作用。方法：采用小鼠高架十字迷宫实验、应激导致孤养小鼠体温升高实验评价解郁丸的抗焦虑活性；戊巴比妥钠阈下催眠剂量实验和延长戊巴比妥钠睡眠时间实验评价其与戊巴比妥钠的协同作用。结果：解郁丸能增加小鼠在开臂内运动时间百分率和抑制应激所致孤养小鼠的体温升高，在小鼠高架十字迷宫与应激导致孤养小鼠体温升高模型上显示出抗焦虑作用；解郁丸对小鼠自主活动无影响，表明其在抗焦虑的剂量下无镇静的副作用。同时解郁丸亦能提高小鼠翻正反射消失数，增加小鼠入睡率；与戊巴比妥钠协同明显延长小鼠睡眠时间。结论：解郁丸有一定的抗焦虑及催眠作用。

The Experimental Research on Anxiolytic and Hypnogenetic Effects of Jieyuwan

Objective:To investigate the anxiolytic and hypnogenetic effects of Jieyuwan on animal models.Methods:The anxiolytic effects of Jieyuwan were tested in the elevated plus-maze(EPM) and stress-induced hyperthermia in singly housed mice(SIH);the hypnosis effects were studied in pentobarbital-induced sleeping time and subthreshold dose of pentobarbital test in mice.Results:Jieyuwan exhibited the anxiolytic effects in mice by increasing the time percentage into the open-arms in the elevated plus-maze and antagonize stress-induced hyperthermia in singly housed mice.Jieyuwan failed to affect the locomotor activity in mice at the test dose,suggesting Jieyuwan did not induce sedation in the anxiolytic doses.Jieyuwan could prolong the time of sleep in pentobarbital-induced sleeping time in mice and increase the percentage of falling asleep in subthreshold dose of pentobarbital test.Conclusion:Jieyuwan has definite antianxiety and hypnotic effects in animal models.