乙肝肝硬化合并自发性细菌性腹膜炎PCT和HBP与IL-7表达水平

目的探究乙肝肝硬化合并自发性腹膜炎腹水降钙素原(PCT),肝素结合蛋白(HBP),白细胞介素-7(IL-7)表达水平对肝功能,肠道屏障功能的影响。方法选取浙江金华广福肿瘤医院2017年1月一2019年7月乙肝肝硬化腹水患者123例作为研究对象,其中合并自发性细菌性腹膜炎(SBP)患者48例为研究组,单纯腹水患者75例为对照组。比较两组患者腹水PCT、HBP、IL-7水平,并分析研究组患者腹水PCT、HBP、IL-7不同表达水平与肝功能谷丙转氨酶(ALT),谷草转氨酶(AST),白蛋白(ALB)]、肠道屏障功能二胺氧化酶(DAO)、内毒素(ET),D-乳酸(D-Lac)]指标的相关性。结果研究组患者腹水PCT、HBP水平分别为(1.04±0.28)ng/ml,(90.26±21.47)ng/ml均高于对照组,IL-7(788,43±176.52)pg/ml低于对照组(P<0.05);Pearson相关性分析结果,腹水PCT HBP水平与肝功能指标ALT、AST呈正相关,与ALB呈负相关,IL-7水平与ALT,AST呈负相关,与ALB呈正相关(均P<0.05);腹水PCT,HBP水平与肠道屏障功能指标DAO、ET,D-Lac呈正相关,IL-7水平与DAO、ET、D-Lac呈负相关(均P<0.05),结论腹水PCT、HBP、IL-7与肝功能,肠道屏障功能密切相关,有助于临床及时确诊﹐为判断病情提供有效信息。

PCT,HBP and IL-7 in ascites of hepatitis B cirrhosis patients complicated with spontaneous bacterial peritonitis

OBJECTIVE To explore the impact of levels of procalcitonin(PCT), heparin-binding protein(HBP) and interleukin-7(IL-7) in ascites of the hepatitis B cirrhosis patients complicated with spontaneous peritonitis on the liver function and intestinal barrier function. METHODS A total of 123 patients with hepatitis B cirrhosis and ascites who were treated in Zhejiang Jinhua Guangfu Hospital from Jan 2017 to Jul 2019 were recruited as the study subjects, 48 of whom were complicated with spontaneous bacterial peritonitis(SBP) and were assigned as the study group, and 75 patients with simple ascites were set as the control group.The levels of PCT, HBP, and IL-7 in ascites were compared between the two groups, and the correlation between the levels of ascites PCT, HBP and IL-7 and the liver function alanine aminotransferase(ALT), aspartate aminotransferase(AST), albumin(ALB)], intestinal barrier function diamine oxidase(DAO), endotoxin(ET), D-lactic acid(D-Lac)] was observed. RESULTS The levels of ascites PCT and HBP of the study group were respectively(1.04±0.28)ng/ml and(90.26±21.47)ng/ml, significantly higher than those of the control group;the IL-7 level of the study group was(788.43±176.52)pg/ml, significantly lower than that of the control group(P<0.05).Pearson correlation analysis showed that the levels of ascites PCT and HBP were positively correlated with ALT and AST and negatively correlated with ALB, the IL-7 level was negatively correlated with ALT and AST and positively correlated with ALB(all P<0.05);the levels of ascites PCT and HBP were positively correlated with the intestinal barrier function indexes DAO, ET and D-Lac, and the IL-7 level was negatively correlated with DAO, ET and D-Lac( all P<0.05). CONCLUSION The ascites PCT, HBP and IL-7 are closely associated with the liver function and intestinal barrier function, which may facilitate the clinical diagnosis and provide effective information for judgement of illness condition.