Efficacy of nebulized liposomal amphotericin B in treatment of experimental pulmonary aspergillosis |
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| Authors: | Gavaldà Joan Martín María-Teresa López Pedro Gomis Xavier Ramírez José-Luís Rodríguez Dolors Len Oscar Puigfel Yolanda Ruíz Isabel Pahissa Albert |
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| Affiliation: | Infectious Diseases Research Laboratory, Infectious Diseases Division, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain. jgavalda@vhebron.net |
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| Abstract: | ![]()
The efficacy of therapeutic aerosolized amphotericin B (AMB) was studied in a steroid-immunosuppressed murine model of invasive pulmonary aspergillosis. Nebulized liposomal AMB can be a valid approach to the treatment of this infection, with subjects showing significantly improved survival relative to that of subjects given intravenous deoxycholate AMB, as well as lower lung weights and pulmonary glucosamine levels. |
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