Haemoglobin F Port Royal (α2Gγ2, 125Glu → Ala) |
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| Authors: | B. Brimhall T. S. Vedvick R. T. Jones E. Ahern E. Palomino V. Ahern |
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| Affiliation: | Department of Biochemistry, University of Oregon Medical School, Portland, Oregon, U.S.A;. Departments of Pathology, University of the West Indies, Jamaica; Departments of Paediatrics, University of the West Indies, Jamaica |
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| Abstract: | S ummary . A Gγ-chain variant, Hb F Port Royal, with an electrophoretic mobility intermediate between Hb S and Hb C, was found in a Jamaican-Negro infant, and made up 14–15% of the total Hb F. A glycinamidation procedure was employed to aid in determining the amino-acid residue substitution of γ125Glu → Ala, and the presence of glycinc in position 136. |
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