Giant Cell Tumor of Soft Tissue with Pulmonary Metastases: Pathologic and Cytogenetic Study |
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Authors: | Hua Guo Roberto A Garcia Mary Ann Perle John Amodio M Alba Greco |
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Institution: | (1) Department of Pathology, Division of Pediatric Pathology, New York University School of Medicine, 560 First Avenue, New York, New York 10016, USA;(2) Department of Pathology, Division of Surgical Pathology, Bellevue Hospital, New York University School of Medicine, New York, New York 10016, USA;(3) Department of Pathology, Division of Cytogenetics, Bellevue Hospital, New York University School ofMedicine, New York, New York 10016, USA;(4) Department of Radiology, New York University School of Medicine, New York, New York 10016, USA |
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Abstract: | Giant cell tumor of soft tissue (GCTST) has gained general acceptance as an uncommon but distinct primary soft tissue tumor
since it was first described in 1972. GCTST is predominantly seen in adults and typically shows uniformly dispersed osteoclast-like
giant cells admixed with oval to polygonal mononuclear cells. It usually follows a benign clinical course, although the malignant
variant has been described in cases in which the mononuclear cells demonstrate obvious dysplastic features. It is still not
clear whether the two variants belong to the spectrum of the same tumor. No cytogenetic chromosomal abnormalities have been
reported in the literature of GCTST. Interestingly, the osseous counterpart of giant cell tumor, which shares similar histologic
features, quite often displays a telomeric association at the cytogenetic level, a finding that has never been reported in
GCTST. We report the case of a 12-year-old girl with GCTST of the right leg that metastasized to the lung. Cytogenetic studies
from the primary tumor showed the phenomenon of telomeric association involving multiple chromosomes. |
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Keywords: | children cytogenetics giant cell tumor soft tissue telomeric association |
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