肥胖儿童血清抵抗素变化及其临床意义

目的 探讨饮食控制和运动疗法对肥胖儿章血清抵抗素水平的影响及其临床意义。方法 测定36例肥胖儿童饮食控制和运动治疗前后血清抵抗素、胆固醇（CHO）、甘油三脂（TG）、低密度脂蛋白胆固醇（LDL-C）、空腹和葡萄糖耐量试验（OGTT）2小时血糖、胰岛素，计算胰岛素抵抗指数（HOMA-IR）。结果 肥胖儿童血清抵抗素水平显著高于对照组（P〈0．05），并与OGTT2小时血糖、胰岛素呈正相关（P〈0．05）；经饮食控制和运动治疗后肥胖儿童血清抵抗素、体重、BMI、血清CHO、TG、LDL-C、空腹和OGTT2小时胰岛素、HOMA-IR显著低于治疗前（P〈0．05），治疗前后空腹和OGTT2小时血糖差异无显著性（P〉0．05）。结论 肥胖儿童血清抵抗素水平升高，并与OGTT2小时血糖、胰岛素呈正相关，推测将来有可能以检测血清抵抗素水平来了解肥胖儿童有否存在糖耐量受损；饮食控制和运动疗法可使肥胖儿童血清抵抗素降低，胰岛素抵抗减轻。

Serum resistin level and its clinical significance in obese children

Objective To investigate the level of serum resistin and its clinical significance in obese children and explore effects of diet control and physical exercise on its changes.Methods Combination therapy of diet control and physical exercise was performed in 36 obese children.At the beginning and end of the treatment,blood sample were taken from each child for determination of serum resistin,insulin,glucose and lipid profile.Results Level of serum resistin was significantly higher in obese group than that in normal control group and positively correlated with serum glucose and insulin 2 h after oral glucose tolerance test(OGTT)(P<0.05).Levels of serum resistin,body weight,BMI,serum glucose,CHO,TG,LDL-C,HOMA-IR,fasting glucose,glucose and insulin 2 h after OGTT were significantly lower after combination therapy of diet control and physical exercise than before in obese children(P<0.05).Conclusions Level of serum resistin in obese children is significantly higher than that in normal controls and positively correlates with serum glucose and insulin 2 h after OGTT.Combination therapy of diet control and physical exercise can decrease level of serum resistin and improve insulin sensitivity in obese children.