| 甘草苷在大鼠体内的代谢途径研究 |
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| 引用本文： | 董世奇,樊慧蓉,李全胜,魏广力,刘万卉,司端运.甘草苷在大鼠体内的代谢途径研究[J].中草药,2014,45(17):2499-2505. |
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| 作者姓名： | 董世奇 樊慧蓉 李全胜 魏广力 刘万卉 司端运 |
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| 作者单位： | 烟台大学, 山东 烟台 246003;天津药物研究院 释药技术与药代动力学重点实验室, 天津 300193;天津药物研究院 释药技术与药代动力学重点实验室, 天津 300193;天津药物研究院 释药技术与药代动力学重点实验室, 天津 300193;天津药物研究院 释药技术与药代动力学重点实验室, 天津 300193;烟台大学, 山东 烟台 246003;天津药物研究院 释药技术与药代动力学重点实验室, 天津 300193 |
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| 摘 要： | 目的研究甘草苷在大鼠体内的代谢途径。方法大鼠ig给予甘草苷300 mg/kg后,收集胆汁、尿液、粪便和血浆,应用高效液相色谱-四级杆-离子阱串联质谱(HPLC-QTRAP-MS)技术分析甘草苷在大鼠体内的代谢途径。结果共检测到除原形药物外的9个代谢产物,提示甘草苷在大鼠体内的主要代谢途径为脱葡萄糖基反应生成甘草素及甘草素的脱氢氧化以及葡糖醛酸化和硫酸化。结论甘草苷在大鼠体内经历了广泛的I相和II相代谢。应用峰面积归一化法计算主要代谢产物相对生成量百分比,甘草苷ig给药后在大鼠胆汁、尿、粪和血浆中的主要代谢产物为甘草素、甘草素的葡萄糖醛酸结合物及其硫酸结合物。
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| 关 键 词： | 甘草苷 代谢途径 代谢产物 高效液相色谱-四级杆-离子阱串联质谱 峰面积归一化法 |
| 收稿时间： | 2014/4/18 0:00:00 |
In vivo metabolic pathway of liquiritin in rats |
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| DONG Shi-qi,FAN Hui-rong,LI Quan-sheng,WEI Guang-li,LIU Wan-hui and SI Duan-yun.In vivo metabolic pathway of liquiritin in rats[J].Chinese Traditional and Herbal Drugs,2014,45(17):2499-2505. |
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| Authors: | DONG Shi-qi FAN Hui-rong LI Quan-sheng WEI Guang-li LIU Wan-hui and SI Duan-yun |
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| Institution: | Yantai University, Yantai 246003, China;State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China;State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China;State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China;State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China;Yantai University, Yantai 246003, China;State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China |
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| Abstract: | Objective To study the in vivo metabolic pathways of liquiritin (LQ) in rats. Methods An HPLC-QTRAP-MS method was established and applied to identify the metabolites of LQ in bile, urine, feces, and plasma after ig administration of LQ (300 mg/kg) to rats. Results A total of nine metabolites were found in rats. The major metabolic pathway of LQ was deglucosidation to liquiritigenin (LG) and dehydration, glucuronidation, and sulfation of LG. Conclusion LQ undergoes extensive phases I and II metabolism in rats. The major metabolites of LQ are LG and its glucuronides and sulfates. |
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| Keywords: | liquiritin metabolic pathway metabolites HPLC-QTRAP-MS peak area normalization method |
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