| 溃平宁颗粒质量标准的研究及确定 |
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| 引用本文： | 李虹,樊飞.溃平宁颗粒质量标准的研究及确定[J].时珍国医国药,2011,22(5):1104-1106. |
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| 作者姓名： | 李虹 樊飞 |
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| 作者单位： | 1. 辽宁省食品药品检验所,辽宁,沈阳,110023
2. 辽宁省妇幼保健院,辽宁,沈阳,110005 |
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| 基金项目： | 国家药品标准提高行动计划 |
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| 摘 要： | 目的研究溃平宁颗粒的质量标准。方法增加TLC法鉴别延胡索、白及及RP-HPLC法测定大黄浸膏的含量。含量采用Waters C18色谱柱(200 mm×4.6 mm,5μm);流动相为甲醇-0.1%磷酸溶液(85:15),流速1 ml·min-1;检测波长:440 nm;用外标法定量。结果鉴别、含量:阴性对照均无干扰;含量:大黄素0.003 824～0.152 96μg(r=0.999 9)、大黄酚0.007 168～0.286 72μg(r=0.999 7)范围内有良好的线性关系,平均加样回收率为97.8%(n=6)。结论所建方法简单、可靠,可用于溃平宁颗粒的质量控制。
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| 关 键 词： | 延胡索、白及 大黄浸膏 溃平宁颗粒 高效液相色谱法 |
Quality Standard for Kuipingning Granules |
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| LI Hong,FAN Fei.Quality Standard for Kuipingning Granules[J].Lishizhen Medicine and Materia Medica Research,2011,22(5):1104-1106. |
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| Authors: | LI Hong FAN Fei |
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| Institution: | LI Hong1,FAN Fei2(Liaoning Provincial Institute for Control of Food and Drug,Shenyang 110023,China,2.Liaoning Provincial Hospital for Maternal and Child Health,Shenyang 110005,China) |
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| Abstract: | Objective To establish a method for the quality standard of Kuipingning Granules.Methods The TLC methods were established for Rhizoma Corydalis,Rhizoma Bletillae and an RP-HPLC method was established for the determination of Rhubarb extract performed on waters C18 analytical column(200 mm×4.6 mm,5 μm) with methanol-0.1%phosphoric acid(85∶15) as the mobile phase flow rate of 1.0 ml·min-1.The detection wavelength was 440nm.Results Negative control had no interference.The linear range was within the range of 0.003 824～0.152 96 μg(r=0.999 9) for rhein and 0.007 168～0.286 72 μg(r=0.999 7) for chrysopharol,and the average recovery(n=6)was 97.8%.Conclusion The method is convenient,reliable and suitable for quality assessment of Kuipingning Granules. |
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| Keywords: | Rhizoma Corydalis、Rhizoma Bletillae Rhubarb extract Kuipingning Granules HPLC |
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