Preparation of chitosan microspheres using membrane emulsification and its size modelling |
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| Authors: | S.-B. Park Y.-J. Jeon H.-Y. Park W.-S. Kim |
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| Affiliation: | 1. Department of Chemical Engineering, College of Engineering and Bioproducts Research Center, Yonsei University, Seoul 120-749, South Korea;2. DDS Team, Pharmaceutical &3. Health Research Institute, Pacific R&4. D Center, 314-1 Bora-Ri, Kiheung-Eup, Yongin-Si, Kyounggi-Do, 449-900, South Korea |
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| Abstract: | The chitosan microspheres were prepared by a membrane emulsification method with variations of the N2 gas pressure and the chitosan concentration. The pressure of N2 gas was varied within the range from 0.2?×?105 to 0.8?×?105?Pa at chitosan concentration 1.5?wt%. In addition, the concentration of chitosan was varied between 0.5?～?2.0?wt% at 0.4?×?105?Pa of N2 gas pressure. Using this method, it is possible to prepare stable emulsions with a very narrow droplet size distribution in comparison with conventional methods. The average size of the microspheres was dependent on the N2 gas pressure and the concentration, that is it was increased with the pressure and the concentration. The modelling of the size for the microspheres according to the concentration was carried out using Macleod's relation and Parkins & Brown equation. The former shows the relationship between density and surface tension and the latter demonstrates the correlation between the volume of the microspheres and the interfacial tension. The modelling results were in good agreement with the experimental data to predict the microspheres size with the variation of concentration. |
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| Keywords: | Chitosan membrane emulsification microsphere size modelling |
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