心脉隆注射液对PCI围手术期心力衰竭患者疗效观察

目的:通过观察经皮冠状动脉介入治疗(Percutaneous Coronary Intervention,PCI)围手术期心力衰竭患者左室射血分数(Left Ventricular Ejection Fraction,LVEF)、血浆N端B型脑钠肽(N-terminal Brain Natriuretic Peptide,NT-pro BNP)水平、左室舒张末期内径(Left Ventricular and Diastolic Diameter LVDD)及6 min步行距离变化,探讨心脉隆注射液对PCI围手术期心力衰竭患者临床疗效。方法:将100例行PCI治疗且围手术期出现心力衰竭的患者随机分为对照组和治疗组,每组50例。两组均给予常规治疗,治疗组在常规治疗的基础上加用心脉隆注射液6 ml+0.9%氯化钠溶液200 ml静脉滴注,2次/d,疗程10 d。通过测定治疗前、治疗10 d后LVEF、LVDD、血浆NT-pro BNP水平比较两组治疗效果。结果:两组治疗后左室射血分数较治疗前明显升高,差异具有统计学意义(P0.05),且治疗组改善程度高于对照组,差异也具有统计学意义(P0.05);两组治疗后LVDD、NT-pro BNP较治疗前明显下降,差异具有统计学意义(P0.05),且治疗10 d后,治疗组LVDD、NT-pro BNP下降程度高于对照组(P0.05);1个月后治疗组6 min步行距离较对照组远,差异具有统计学意义(P0.05)。结论:心脉隆注射液可明显改善PCI围手术期心力衰竭患者心功能,显著降低血浆NT-pro BNP水平。

Effectiveness of Xinmailong Injection in PCI perioperative patients with heart failureYuan Lixia,Hu Yonghui,Huang Jianfeng,XiaoShanhua.,Zhao Yu,Qin Yanping,Zhao Hua,Huang Shaolie

Objective: By observing the change of left ventricular ejection fraction (LVEF), plasma N-terminal brain natriuretic peptide (NT-pro BNP) level and 6-minute walk distance of the percutaneous coronary intervention (PCI) perioperative patients with heart failure, to explore the effects of Xinmailong injection in PCI perioperative patients with heart failure. Methods: 100 Patients with developed heart failure and PCI perioperative were randomized into control group and treatment group, 50 cases in each groups. The two groups were both given routine treatment. The treatment group was added 6 ml Xinmailong injection + 200 ml 0.9% sodium chloride solution, 2 times/day, for ten days. The change of the plasma levels of NT-pro BNP and LVEF before and 10 days after treatment were compared between the two groups. Results: The left ventricular ejection fraction of the two groups after treatment were increased, the difference was statistically significant (P<0.05); and the LVEF of the treatment group improved higher than the control group, the difference was statistically significan (P<0.05); the LVDd and NT-pro BNP levels of the two groups after treatment were reduced than before treatment, the difference was statistically significant (P<0.05), and 10 days after treatment, the treatment group was higher than the control group (P<0.05); after one month, the 6-minute walk distance of the treatment group was farther than the control group, the difference was statistically significant (P<0.05). Conclusion: Xinmailong injection can improve cardiac function and reduces the level of plasma NT-pro BNP in patients who were PCI perioperative patients with heart failure.