Heparin-immobilized pluronic/PVA composite microparticles for the sustained delivery of ionic drug |
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| Authors: | Hwa Young Park Keun Sang Oh Hyoung Mo Koo Sun Hang Cho Sang Jun Chung Yong Taik Lim |
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| Affiliation: | 1. Department of Advanced Materials, Hannam University, Yususng, Daejeon, Korea;2. Nanobiomaterials Laboratories, Yusung, Daejeon, Korea;3. BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, Yusung, Daejeon, Korea |
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| Abstract: | Heparin-immobilized Pluronic (F-68)/Polyvinylalcohol (PVA) composite microparticles were designed and characterized for the sustained drug delivery of ionic drug. Venlafaxine, antidepressant medication, was used as a model drug. For the efficient loading of ionic drug, heparin was immobilized into F-68/PVA composite microparticles. Differential scanning calorimetry (DSC) was used to understand the intra/intermolecular interactions in the heparin-immobilized F-68/PVA composite gels containing model drug. For the application as a sustained drug delivery system, the loading amount and release pattern of loaded drug were measured using high performance liquid chromatography (HPLC). |
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| Keywords: | Microparticle pluronic polyvinylalcohol heparin sustained release of ionic drug |
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