A HhaI/BstUI polymorphism in a novel gene at human chromosome 11p15.5 |
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| Authors: | Kiyonori Miura Hideaki Masuzaki Tadayuki Ishimaru Norio Niikawa Y Jinno |
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| Institution: | (1) Department of Human Genetics, Nagasaki University School of Medicine, 1-12-4 Sakamoto, Nagasaki, 852-8523 Japan Tel. +81-95-849-7176; Fax +81-95-849-7121 e-mail: siriusyj@net.nagasaki-u.ac.jp, JP;(2) Department of Obstetrics and Gynecology, Nagasaki University School of Medicine, Nagasaki, Japan, JP |
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| Abstract: | We found a HhaI/BstUI polymorphism in the 3′ untranslated region of a novel gene which was localized to 11p15.5. This region is one of prominent
imprinting domains and contains multiple imprinted genes, such as H19, IGF2 , KVLQT1, and p57
KIP2
, which suggests that regional factors might contribute to the imprinting.
This polymorphism will be useful in the allelic analysis of expression and methylation of the novel gene.
Received: July 24, 1998 / Accepted: July 29, 1998 |
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| Keywords: | Imprinting 11p15 5 polymorphism PCR-RFLP |
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