氟西汀治疗卒中后抑郁的疗效和安全性比较——Meta分析

目的通过Meta分析研究氟西汀治疗卒中后抑郁的疗效与安全性。方法全面检索与氟西汀治疗卒中后抑郁的随机对照研究试验报告。从347篇文献中选出14篇随机对照研究（1321例）,利用Revman5.0软件对录入数据进行Meta分析。结果患者氟西汀治疗后的汉密顿抑郁量表（HAMD）评分、临床神经功能缺损程度（CSS）评分、Barthel指数均较治疗前有显著性差异,总不良反应为4.4%。结论氟西汀对卒中后患者的抑郁症状、神经功能缺损均有显著的改善作用,且不良反应少。

Meta-analysis of Fluoxetine for the efficacy and safety of poststroke depression in patients

Objective： Evaluate the efficacy and safety of fluoxetine in patients of post-stroke depression. Methods： To search the reports of randomized control trials of fluoxetine for post-stroke depression,14 clinical randomized control trials（ 1110 patients） were included from 347 reports. Results： Patients with fluoxetine in the treatment of the Hamilton Depression Scale（ HAMD）,clinical neural function defect degree（ CSS）,Barthel index were significantly different,the total adverse reaction was 4. 4%. Conclusion： Fluoxetine on post-stroke patients had depressive symptoms,nerve function defect significantly improved effect,and less adverse reaction.