| 甲孕酮对K562/AO2细胞及P-gp、Bcl-2耐药蛋白表达的影响 |
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| 引用本文： | 王双. 甲孕酮对K562/AO2细胞及P-gp、Bcl-2耐药蛋白表达的影响[J]. 泰山医学院学报, 2014, 0(8): 720-722 |
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| 作者姓名： | 王双 |
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| 作者单位： | 泰山医学院附属泰安医院肿瘤内科,山东泰安271000 |
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| 摘 要： | 目的：探讨甲孕酮对白血病 K562/ AO2细胞凋亡率及 P - gp、Bcl -2耐药蛋白表达的影响。方法以 MTT法检测肿瘤细胞增殖的抑制率,流式细胞术检测肿瘤细胞凋亡、P - gp 及 Bcl -2表达。结果甲孕酮能够提高 K562/AO2细胞的凋亡,能够下调 K562/ AO2细胞 P - gp、Bcl -2的表达。结论甲孕酮能提高 K562/ AO2细胞化疗敏感性,促进其凋亡,对 K562/ AO2细胞有一定的逆转耐药作用。
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| 关 键 词： | K562/A02细胞株 甲孕酮 Bd-2蛋白 P-gp蛋白 |
Effect of medroxyprogesterone acetate on K562/AO2 cells and P - gp,Bcl - 2 resistance protein expression |
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| WANG Shuang. Effect of medroxyprogesterone acetate on K562/AO2 cells and P - gp,Bcl - 2 resistance protein expression[J]. Journal of Taishan Medical College, 2014, 0(8): 720-722 |
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| Authors: | WANG Shuang |
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| Affiliation: | WANG Shuang (Central Hospital of Taian City, Internal Medicine- Oncology, Taian 271000 ,China) |
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| Abstract: | Objective：To investigate the effect of MPA on leukemia K562 / AO2 cell apoptosis rate and expression of P -gp,Bcl - 2 resistance protein. Methods：To inhibit the proliferation of tumor cells was detected by MTT rate,to detect the ex-pression of P - gp and Bcl - 2 tumor cell apoptosis,flow cytometry. Results：MPA can improve the K562 / AO2 cell apoptosis, downregulate the expression of K562 / AO2 cells P - gp,Bcl - 2. Conclusion：MPA can improve the chemotherapeutic sensitivi-ty of K562 / AO2 cell,promote the apoptosis of reversal of multidrug resistance,have certain effect on K562 / AO2 cells. |
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| Keywords: | K562/AO2 Medroxyprogesterone acetate（MPA） Bel- 2 protein P-gp protein |
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