血清胆红素水平与非酒精性脂肪肝发病关系的研究

目的：探讨血清胆红素与非酒精性脂肪性肝病（nonalcoholic fatty liver disease，NAFLD）发生的关系。方法选择2010年5月-2013年6月在我院消化内科住院的120例成人非酒精性脂肪肝患者和相匹配的对照者120例，空腹抽取静脉血检测 TBil、DBil、间接胆红素、ALT、TG、高密度脂蛋白胆固醇、空腹血糖、尿酸等。结果患者 TBil、DBil、间接胆红素水平都低于对照组；血清 TBil 水平与 BMI、TG 呈负相关（r =-0.234、0.268，P 均﹤0.05），与高密度脂蛋白胆固醇呈正相关（ r =0.225，P ﹤0.05），DBil 和间接胆红素与上述指标也有类似的相关性（ r =0.293、0.262、0.168和0.159、0.193、0.069，P 均﹤0.05）；逐步选择法 Logistic 回归分析发现，TBil 与 NAFLD 患病有关（P ﹤0.01）。结论血清胆红素水平较低患者 NAFLD 患病的风险增加。

Relationship of incidance and serum bilirubin in patients with nonalcoholic fatty liver disease

Objective：To explore the relationship of nonalcoholic fatty liver disease（NAFLD）incidance with serum bil-irubin. Methods：One hundred and twenty patients with NAFLD and 120 healthy cases were studied. Serum bilirubin, HDL,LDL,TG,Uric acid,blood glucose and ALT were measued to analyze the relationship of incidance and serum biliru-bin in patients with nonalcoholic fatty liver disease. Results：Both serum total bilirubins were markedly correlated with inci-dences of NAFLD. Conclusion：Cases with lower serum total bilirubin are prone to incidences of NAFLD.