Gemcitabine and vinorelbine combination is effective in both as a salvage and mobilization regimen in relapsed or refractory Hodgkin lymphoma prior to ASCT |
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Authors: | Elif Suyan? Gülsan Türköz Sucak ?ahika Zeynep Ak? Zeynep Arzu Ye?in Zübeyde Nur Özkurt Münci Ya?c? |
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Institution: | (1) Department of Hematology Ankara, Gazi University Faculty of Medicine, Beşevler, 06500 Ankara, Turkey |
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Abstract: | We investigated the efficacy of gemcitabine and vinorelbine (Gem/Vin) combination chemotherapy as a salvage and mobilization
regimen in relapsed or refractory Hodgkin lymphoma (HL) patients prior to autologous hematopoietic stem cell transplantation.
We retrospectively reviewed the data of our relapsed or primary refractory HL patients treated with Gem/Vin regimen which
consisted of gemcitabine 1,000 mg/m2/day and vinorelbine 30 mg/m2/day on days 1, 8, and 15 every 28 days. The overall response rate was 72.4%. Ten (34.5%) patients achieved complete remission,
11 (37.9%) partial remission, and eight (27.6%) patients had no response. Mobilization with Gem/Vin regimen was successful
in 20/23 (87%) patients while mobilization failure was seen in three (13%) patients. Gemcitabine and vinorelbine is an effective
salvage regimen with acceptable toxicity and high mobilization potential in relapsed or refractory HL patients. |
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