| 穿孔素和颗粒酶-生物导弹的理想材料 |
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| 引用本文： | 董红梅.穿孔素和颗粒酶-生物导弹的理想材料[J].生物医学工程学杂志,2005,22(5):1075-1077. |
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| 作者姓名： | 董红梅 |
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| 作者单位： | 汕头大学医学院法医教研室 汕头515041
(董红梅，徐小虎)，汕头大学医学院法医教研室 汕头515041(于晓军) |
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| 基金项目： | 国家自然科学基金资助项目(30070291)，广东省卫生厅基金资助项目(A2000434) |
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| 摘 要： | 穿孔素和颗粒酶是细胞毒性细胞两类重要的效应分子,能导致被病原体感染的细胞和肿瘤细胞发生凋亡。随着对疾病靶向性治疗研究的进展,生物导弹的研究也倍受瞩目。根据穿孔素和颗粒酶的生物学特点,有望在生物导弹的应用中占有一席之地,本文就这方面的问题作一综述。
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| 关 键 词： | 穿孔素 颗粒酶 生物导弹 |
Perforin and Granzyme-the Perfect Material of Biologic Missile |
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| Dong Hongmei,Xu Xiaohu, Yu Xiaojun.Perforin and Granzyme-the Perfect Material of Biologic Missile[J].Journal of Biomedical Engineering,2005,22(5):1075-1077. |
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| Authors: | Dong Hongmei Xu Xiaohu Yu Xiaojun |
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| Institution: | Department of Forensic Medicine, Medical College of Shantou University, Shantou 515041 ,China |
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| Abstract: | Perforin and granzyme are important effector molecules in cytolytic cells.They can induce apoptosis of tumor cells and infection cells. The research of biologic missile is noticed with the progress in therapy targeting to the disease. It is supposed that perforin and granzyme play an important role in biological missiles because of their biologic function and structure. A review on several aspects of these effector molecules is presented. |
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| Keywords: | Perforin Granzyme Biologic missiles |
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